支持细胞调控精原干细胞增殖、分化和凋亡的研究进展

doi:10.11843/j.issn.0366-6964.2016.02.003

Abstract

Abstract:

The proliferation，differentiation and apoptosis of spermatogonial stem cells (SSCs) are regulated orderly by sertoli cells (SCs) and maintain the spermatogenesis of male animals.This review focuses on the relationship of physical structure between SCs and SSCs，and the regulation for the proliferation，differentiation and apoptosis of SSCs by GDNF，FGF2，RA，BMP4，SCF，FasL and SR-BI which are SCs-derived factors.This information provides an important reference for the further studies of spermatogenesis and will have great significance to improve reproductive efficiency of male animals，and also provides a valuable reference to explore the clinical treatment of male infertility disease.

CLC Number:

S814

LIANG Ming-yuan，ZHU Hua-bin，CHEN Xiao-li，HAO Hai-sheng，ZHAO Xue-ming，QIN Tong，WANG Dong. The Study Progress of the Proliferation，Differentiation and Apoptosis of Spermatogonial Stem Cells under the Regulation of Sertoli Cells[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(2): 225-231.

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The Study Progress of the Proliferation，Differentiation and Apoptosis of Spermatogonial Stem Cells under the Regulation of Sertoli Cells

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